Pepperdine, which won by s cores of 15-4, 15-9, 14-16, 17-15, will host Kansas State in a second round match on Saturday beginning at 7 p.m.
The Wildcats (21-8) defeated Loyola-Chicago by scores of 15-7, 15-4, 6-15, 15-9 in a first round match.
Junior outside hitters Lisa Borom and Melissa Snow also recorded double-doubles for Pepperdine, which improved to 24-6. Borom tallied 16 kills and 10 digs, while Snow had 10 kills and 15 digs.
Pepperdine had a chance to win the match in three games, but Fairfield rallied from an 11-14 deficit and held off two-match points to post a 16-14 win.
The Stags, who finished their season with a 26-7 record, held off three match points in Game Four before eventually falling 17-15.
The victory marks the third straight year that Pepperdine has won a first-round match. Junior outside hitter Joanne Saunders recorded a double-double as she totaled a match-high 27 kills and 13 digs for Fairfield. Sophomore middle blocker Conny Paul added 25 kills and 13 digs to register a double-double for the Stags.
In the evening's first match, junior outside hitter Liz Wegner tallied a match-high 23 kills and recorded a .300 hitting percentage to lead Kansas State. Freshman outside hitter Cari Jensen and Kelle Branting also finished with double-digit kill totals with 14 and 12, respectively. Junior outside hitter Sarah Poglits had a double-double (15 kills and 10 digs) to lead Loyola-Chicago.