The Waves won by scores of 30-18, 30-27, 30-23 to improve to 4-2 on the season. The Irish had their record evened at 3-3.
Sophomore outside hitter Katie Wilkins totaled a match-high 16 kills, had nine digs and recorded a .382 hitting percentage to lead Pepperdine.
Freshman outside hitter Brie Harris continued her solid play as she posted her third double-double of the season, recording 14 kills and 12 digs.
Sophomore middle blocker Lyndsey Hache' finished in double figures with 12 kills and registered a .393 hitting percentage for the Waves.
Pepperdine registered a .250 hitting percentage, while Notre Dame hit .129 for the match.
The Waves return to action on Friday, September 14, when they face host North Carolina in the Carolina Nike Classic beginning at 4 p.m.