The Waves won by scores of 33-31, 31-29, 30-25 for their season-high 10th win in a row and improve to 20-3 overall and 13-0 in WCC play.
Pepperdine will attempt to register its second undefeated conference season in the last three years when it hosts Saint Mary's in its regular season finale on Saturday beginning at 7 p.m.
San Diego, attempting to secure an NCAA Tournament at-large berth, dropped to 20-8 overall and 9-4 in WCC play.
Sophomore middle blocker Lyndsey Hache' totaled a team-high 13 kills, while freshman outside Brie Harris added 11 kills for the Waves. Pepperdine had four players reach double digits in kills as junior setter Paola Rodriguez had a match-high 15. Sophomore outside hitter Katie Wilkins and senior outside hitter Melissa both contributed 11.