The Waves won by scores 30-19-30-16, 30-19 to improve to 24-6 on the season and advance to a second round match against cross-town rival UCLA on Friday at Firestone Fieldhouse beginning at 7 p.m.
The victory was also Pepperdine's 15th in a row tying the school record for most consecutive wins established during the 1991 season.
Cal Poly concluded its season with a 15-13 mark.
The Bruins reached the second round with a sweep of Long Beach State, winning by scores of 30-25, 30-27, 30-21.
Pepperdine played an all-around solid match as it registered a .475 hitting percentage and had six players with a .300-or-better hitting mark.
Junior middle blocker Lyndsey Hache' recorded 11 kills and hit .667 while senior middle blocker Stacy Rouwenhorst contributed 11 kills and posted a .474 hitting percentage.
"At the beginning of the season we as a team set goals that we wanted to accomplish this season," head coach Nina Matthies said. "Our first goal was to go 14-0 in conference and we accomplished that.
"Now it is a six-step process and and we have accomplished Step 1," Matthies added.
In addition to a strong offensive showing, Pepperdine also played solid defense as it recorded 50 digs and limited Cal Poly to a 0.93 hitting percentage.